Purpose. This study investigated the infection status and relationship between other common lower genital tract infectious pathogens and high-risk human papillomavirus (HR-HPV) in the high-grade cervical lesions. Methods. Overall, 882 patients were enrolled in this retrospective study, of which 339 patients (≥HSIL group) were confirmed with high-grade squamous intraepithelial lesions (HSIL) or cervical squamous cell carcinoma (SCC), while 543 patients (≤LSIL group) were diagnosed with low-grade squamous intraepithelial lesions (LSIL) or normal cervical pathology diagnosis. Cervical swab specimens were tested for HPV, pathogenic bacteria (PB), U. urealyticum (UU), M. hominis (MH), and C. trachomatis (CT) in both groups. Results. The infection rates of HR-HPV, PB, UU (at high density), and CT were higher in the ≥HSIL group than in the ≤LSIL group (); however, higher infection rates with MH were not observed (). PB, UU, and CT were associated with HR-HPV infection (). The PB and UU infection rates in the ≥HSIL group were significantly different from those in the ≤LSIL group, regardless of whether there was an HR-HPV infection at the same time (). However, this was not the case for the CT (). Furthermore, 259 pathogenic bacterial strains were detected in 882 cases. The difference in the distribution of pathogenic bacterial flora in the different grades of cervical lesions had no statistical significance, which was prioritized over Escherichia coli (). Conclusion. PB, UU, and CT infection is associated with susceptibility to HR-HPV, HR-HPV coinfection with these pathogens might increase the risk of high-grade cervical lesions, and PB and UU might be independent risk factors for cervical lesions.

中文翻译：

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高危人乳头瘤病毒和下生殖道病原体在高级别宫颈病变发展中的共同感染。

目的。本研究调查其他常见下生殖道感染病原体与高危型人乳头瘤病毒（HR-HPV）在高级别宫颈病变中的感染状况及关系。方法。总体而言，该回顾性研究共纳入 882 例患者，其中 339 例患者（≥HSIL 组）确诊为高级别鳞状上皮内病变（HSIL）或宫颈鳞状细胞癌（SCC），而 543 例患者（≤LSIL 组）为诊断为低度鳞状上皮内病变（LSIL）或正常宫颈病理诊断。对两组的宫颈拭子样本进行 HPV、致病菌 (PB)、解脲脲原体(UU)、人型分枝杆菌(MH)和沙眼衣原体(CT) 检测。结果。≥HSIL组的HR-HPV、PB、UU（高密度）和CT感染率高于≤LSIL组（); 然而，没有观察到更高的 MH 感染率（）。PB、UU 和 CT 与 HR-HPV 感染相关（）。≥HSIL组的PB和UU感染率与≤LSIL组有显着差异，无论是否同时存在HR-HPV感染（）。然而，CT 并非如此（）。882例检出259株病原菌。宫颈病变不同级别病原菌群分布差异无统计学意义，优先于大肠埃希菌。）。 结论。PB、UU、CT感染与HR-HPV易感性相关，HR-HPV合并感染这些病原体可能增加宫颈高级别病变的风险，PB和UU可能是宫颈病变的独立危险因素。