Abuse of heroin (diamorphine) and heroin-related deaths remain a problem of concern in many countries. In cases of fatal intoxication, the confirmation of heroin abuse as a contributory factor to death frequently depends on evidence obtained from the examination of postmortem reports, police reports and witness statement. Nevertheless, the detection of the specific metabolite of heroin, 6-acetylmorphine (6-AM), is the best marker of recent heroin intake in postmortem samples as a consequence of the rapid metabolism of heroin. However, esterase-mediated conversion of 6-AM to morphine occurs quickly in blood (half-life of 6-AM in blood: 6 to 25 min), and consequently, 6-AM can usually be...

中文翻译：

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在与海洛因有关的死亡中，在玻璃体幽默中进行6-乙酰吗啡的检测似乎比血液或尿液中的敏感性更高。

在许多国家，滥用海洛因（二甲吗啡）和海洛因相关的死亡仍然是一个令人关注的问题。在致命性陶醉的情况下，确认海洛因滥用是导致死亡的一个因素，通常取决于从验尸报告，警察报告和证人证词中获得的证据。尽管如此，由于海洛因的快速代谢，检测海洛因的特定代谢产物6-乙酰吗啡（6-AM）是死后样品中最近摄入海洛因的最佳标志。但是，酯酶介导的6-AM向吗啡的转化在血液中迅速发生（6-AM在血液中的半衰期：6至25分钟），因此6-AM通常可以...