Abstract Despite the adverse effects of microbial hazards on public health, major pharmaceutical firms have left the field of anti-infective development and a dramatic reduction in the number of researcher's intricated in the quest for new specific anti-infective leads. In the non-existence of an efficient forum for antibiotics development and over usage in human beings and animals, bacteria have demoralized this potential by gradually establishing the resistance toward most of the antibiotics used. Thus, the production of novel and successful anti-infective drugs is urgently required to combat this resistance. Hydrazones and hydrazides have mounted as a key-skeleton for the development of active drugs, due to their important biological and pharmacological profiles. Hydrazones are being manufactured as medicines by various investigators to fight against the ailments with maximal effects and minimal toxicity. This paper focuses on the outline of the literature results of recent years, incorporating the work on the anti-infective profile of hydrazone analogues. This review may also act as an excellent basis for the development of new derivatives of hydrazone as potential anti-infective mediators.

中文翻译：

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包含化合物腙作为有前景的抗感染剂：化学和结构-性质关系

摘要 尽管微生物危害对公众健康有不利影响，但主要的制药公司已经离开了抗感染开发领域，并且在寻找新的特定抗感染线索的​​研究人员数量急剧减少。由于缺乏有效的抗生素开发论坛以及人类和动物的过度使用，细菌逐渐对大多数使用的抗生素产生抗药性，从而削弱了这种潜力。因此，迫切需要生产新型且成功的抗感染药物来对抗这种耐药性。由于其重要的生物学和药理学特征，腙和酰肼已成为开发活性药物的关键骨架。各种研究人员将腙作为药物制造，以最大的效果和最小的毒性对抗疾病。本文重点概述了近年来的文献结果，并结合了腙类似物抗感染特性的工作。该综述还可以作为开发腙新衍生物作为潜在抗感染介质的极好基础。