This work is aimed to develop a biocompatible, bactericidal and mechanically stable biomaterial to overcome the challenges associated with calcium phosphate bioceramics. The influence of chemical composition on synthesis temperature, bioactivity, antibacterial activity and mechanical stability of least explored calcium silicate bioceramics was studied. The current study also investigates the biomedical applications of rankinite (Ca₃Si₂O₇) for the first time. Sol-gel combustion method was employed for their preparation using citric acid as a fuel. Differential thermal analysis indicated that the crystallization of larnite and rankinite occurred at 795°C and 1000°C respectively. The transformation of secondary phases into the desired product was confirmed by XRD and FT-IR. TEM micrographs showed the particle size of larnite in the range of 100-200 nm. The surface of the samples was entirely covered by the dominant apatite phase within one week of immersion. Moreover, the compressive strength of larnite and rankinite was found to be 143 MPa and 233 MPa even after 28 days of soaking in SBF. Both samples prevented the growth of clinical pathogens at a concentration of 2 mg/mL. Larnite and rankinite supported the adhesion, proliferation and osteogenic differentiation of hBMSCs. The variation in chemical composition was found to influence the properties of larnite and rankinite. The results observed in this work signify that these materials not only exhibit faster biomineralization ability, excellent cytocompatibility but also enhanced mechanical stability and antibacterial properties.

这项工作旨在开发一种生物相容性，杀菌性和机械稳定性的生物材料，以克服与磷酸钙生物陶瓷相关的挑战。研究了化学组成对探索最少的硅酸钙生物陶瓷的合成温度，生物活性，抗菌活性和机械稳定性的影响。当前的研究还研究了兰金石（Ca ₃ Si ₂ O ₇）。采用溶胶-凝胶燃烧法以柠檬酸为燃料进行制备。差热分析表明，菱铁矿和兰金石的结晶分别在795℃和1000℃下发生。通过XRD和FT-IR证实了第二相向所需产物的转化。TEM显微照片显示菱锰矿的粒度在100-200nm范围内。样品的表面在浸入一周内完全被磷灰石相覆盖。另外，即使在SBF中浸泡28天，拉铝石和树突石的抗压强度也分别为143MPa和233MPa。两种样品均以2 mg / mL的浓度阻止了临床病原体的生长。拉尼石和兰金石支持了黏附，增殖和成骨分化的hBMSCs。发现化学组成的变化会影响菱锰矿和兰尼石的性能。在这项工作中观察到的结果表明，这些材料不仅表现出更快的生物矿化能力，出色的细胞相容性，而且还增强了机械稳定性和抗菌性能。