A series of C-7, C-9 and C-10 modified taxane analogues were synthesized and their in vitro anticancer activities against three human cancer cell lines: A-549 (human lung cancer cell line), MDA-MB-231 (human breast cancer cell line), A-549/T (human lung cancer resistant cell line) were studied. The novel 1-deoxybaccatin VI derivatives modified with carbonate group at C-9 and C-10 positions enable the behavior of these compounds to be evidently distinct from other similar compounds. The strong cytotoxicity in the three cell lines, especially in drug-resistant cell line, showed by the newly synthesized taxane analogues indicated them as potential lead compounds for anticancer drug design.

合成了一系列经C-7，C-9和C-10修饰的紫杉烷类似物，它们对三种人类癌细胞系：A-549（人类肺癌细胞系），MDA-MB-231（人类）具有体外抗癌活性。乳腺癌细胞系），A-549 / T（抗人肺癌细胞系）进行了研究。在C-9和C-10位置用碳酸酯基修饰的新型1-脱氧浆果赤霉素VI衍生物使这些化合物的行为与其他类似化合物明显不同。新合成的紫杉烷类似物在这三种细胞系中，特别是在耐药细胞系中具有很强的细胞毒性，表明它们是抗癌药物设计的潜在先导化合物。