Abstract

Cardiovascular disease (CVD) is one of the main causes of mortality for middle-aged and elderly people in developed countries. The early diagnostic of CVD in middle-aged and elderly people is often hampered by the absence of characteristic clinical picture of the disease. The early diagnosis of atherosclerosis, coronary heart disease (CHD), and myocardial infarction (MI) and their correction improves the survival prognosis and the quality of life of patients. The concentration of the cardinal troponins hs-cTnT and hs‑cTnI, ICAM-1, the adhesion molecules V-CAM1, E-LAM1, and the IL-1α, 1β, -4, -5, -6, -13, -17 cytokines in blood plasma were studied in order to assess the effectiveness of the treatment of atherosclerosis, CHD, and MI. The study of the concentration of ICAM-1, growth factor GDF15, and the NOTCH1 transmembrane protein in blood plasma and urine was recommended for the predictive diagnostic of these diseases. Assessment of the expression of these signal molecules in peripheral tissues for the prediction and prognosis of CVD is a rapidly developing area of molecular medicine and gerontology.

中文翻译：

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肌钙蛋白，黏附分子和白介素作为CVD的诊断标志物：在外周组织中的表达

摘要

心血管疾病（CVD）是发达国家中老年人死亡的主要原因之一。由于缺乏该病的特征性临床表现，常常阻碍了中老年人CVD的早期诊断。动脉粥样硬化，冠心病（CHD）和心肌梗塞（MI）的早期诊断及其纠正可改善患者的生存预后和生活质量。主要肌钙蛋白hs-cTnT和hs-cTnI，ICAM-1，黏附分子V-CAM1，E-LAM1和IL-1α，1β，-4，-5，-6，-13，-的浓度为了评估动脉粥样硬化，冠心病和心梗的疗效，研究了血浆中的17种细胞因子。ICAM-1，生长因子GDF15，建议将血浆和尿液中的NOTCH1跨膜蛋白用于这些疾病的预测诊断。评估这些信号分子在外周组织中的表达以预测和预测CVD是分子医学和老年医学的快速发展领域。