One hundred patients with ischemic heart disease and 70 healthy subjects were on unified regimen. Urine was collected with 4-h proportions during 3–5 days (72–120 h). Each portion of urine was analyzed for macro- (Na, K, P, Cl, Ca, Mg) and microelements (Fe, Cu, Zn, Cr, Cd, V). Temporal structure (biological and hydrometeorological indices) parameters have been estimated by nonlinear least squares method for sinusoidal rhythms and dispersion analysis for nonsinusoidal rhythms. Data of weather indices were received from the hydrometeorological service of the Republic of Armenia in 2015 at 3-h intervals. Statistically significant rhythms were observed in healthy subjects in 91% cases of 593 rhythmological investigations of water-mineral homeostasis. Acrophases of water-mineral homeostasis mostly had individual nature. Healthy subjects’ rhythms of water-mineral excretion were depending on rhythms of hydrometeorological indices and were characterized with significant correlative connections. Acrophases of indices of water-mineral homeostasis mostly were outstripping the acrophases of the rhythms of hydrometeorological indices. Chronostructure of water-mineral homeostasis in patients with ischemic heart disease was characterized with infradian and circadian fluctuations. In case of individuals with ischemic heart disease, statistically significant correlative connections between rhythms of water-mineral excretion and rhythms of hydrometeorological indices differ in comparison with the results of practically healthy individuals. In patients with ischemic heart disease, acrophases of biorhythms often were concurrent or delayed relative to the acrophases of the rhythms of hydrometeorological indices.

中文翻译：

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水文气象指标对缺血性心脏病患者电解质及微量元素稳态的影响

100名缺血性心脏病患者和70名健康受试者采用统一方案。在 3-5 天（72-120 小时）期间以 4 小时的比例收集尿液。对每一部分尿液进行宏观（Na、K、P、Cl、Ca、Mg）和微量元素（Fe、Cu、Zn、Cr、Cd、V）分析。时间结构（生物和水文气象指标）参数已通过非线性最小二乘法估计正弦节律和非正弦节律的色散分析。2015 年，每隔 3 小时从亚美尼亚共和国水文气象服务处收到天气指数数据。在 593 次水-矿物质稳态节律学调查中，91% 的健康受试者的节律具有统计学意义。水-矿物质稳态的晚期阶段大多具有个体性。健康受试者的水-矿物质排泄节律取决于水文气象指标的节律，并具有显着的相关联系。水-矿物质稳态指标的顶峰期大多超过了水文气象指标节律的顶峰期。缺血性心脏病患者的水-矿物质稳态的时间结构以亚昼夜节律波动为特征。对于患有缺血性心脏病的个体，与实际健康个体的结果相比，水-矿物质排泄节律与水文气象指标节律之间的统计学显着相关关系不同。在缺血性心脏病患者中，