Nearly all mammalian tumors of diverse tissues are believed to be dependent on fermentative glycolysis, marked by elevated production of lactic acid and expression of glycolytic enzymes, most notably lactic acid dehydrogenase (LDH). Therefore, there has been significant interest in developing chemotherapy drugs that selectively target various isoforms of the LDH enzyme. However, considerable questions remain as to the consequences of biological ablation of LDH or upstream targeting of the glycolytic pathway.

中文翻译：

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全转录组分析的乳酸脱氢酶A / B或葡萄糖6-磷酸异构酶的双基因敲除建立的完全可行的能源效率的糖酵解无效癌细胞。

据信几乎所有不同组织的哺乳动物肿瘤都依赖于发酵性糖酵解，其特征在于乳酸的产生增加和糖酵解酶的表达，最明显的是乳酸脱氢酶（LDH）。因此，对开发选择性靶向LDH酶的各种同工型的化学疗法药物具有极大的兴趣。然而，关于LDH的生物消融或糖酵解途径的上游靶向的后果，仍然存在很多问题。