Deregulated activation of signaling through the RAS/RAF/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/RAF/MEK/ERK) and signal transducer and activator of transcription (STAT) pathways is involved in numerous hematological malignancies, making it an attractive therapeutic target. This study aimed to assess the effect of the combination of ERK2 inhibitor VX-11e and STAT3 inhibitor STA-21 on acute lymphoblastic leukemia cell lines REH and MOLT-4.

中文翻译：

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ERK2和STAT3抑制剂的组合促进对急性淋巴细胞白血病细胞的抗癌作用。

通过RAS / RAF /丝裂原激活的蛋白激酶/细胞外信号调节激酶（RAS / RAF / MEK / ERK）和信号转导子及转录激活子（STAT）通路引起的信号转导失调参与了许多血液系统恶性肿瘤的治疗，有吸引力的治疗目标。这项研究旨在评估ERK2抑制剂VX-11e和STAT3抑制剂STA-21联合使用对急性淋巴细胞白血病细胞REH和MOLT-4的影响。