Prostate cancer (PCa) is the second-most commonly occurring cancer among men, worldwide. Although the mechanisms associated with the progression of castration-resistant prostate cancer (CRPC) have been widely studied, the mechanism associated with more distant metastases from the bone remains unknown. This study aimed to characterize potential pathogenic kinases associated with highly metastatic PCa, that may regulate phosphorylation in extensively involved and diverse signaling pathways that are associated with the development of various cancers.

中文翻译：

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使用全球比较磷酸化蛋白质组分析对与PC-3M细胞迁移增加有关的激酶表达进行表征。

前列腺癌（PCa）是全球男性中第二常见的癌症。尽管与去势抵抗性前列腺癌（CRPC）进展相关的机制已得到广泛研究，但与骨骼远处转移相关的机制仍然未知。这项研究旨在鉴定与高度转移性PCa相关的潜在病原性激酶，这些激酶可能调节与多种癌症发展相关的广泛参与的多种信号通路中的磷酸化。