MicroRNAs (miRs) play an important role in the regulation of cancer-related processes and are promising candidates for cancer biomarkers. The aim of the study was to evaluate the association of response to anti-EGFR monoclonal antibodies (mAbs) with selected miR expression profiles, including miR-125b, let-7c, miR-99a, miR-17, miR-143 and miR-145 in metastatic colorectal cancer (mCRC) patients.

中文翻译：

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转移性结直肠癌患者中miR-125b，miR-17和let-7c失调与对抗表皮生长因子受体单克隆抗体的反应相关。

MicroRNA（miR）在调节癌症相关过程中起重要作用，并且有望成为癌症生物标志物的候选者。这项研究的目的是评估针对抗EGFR单克隆抗体（mAb）的反应与选定的miR表达谱的相关性，包括miR-125b，let-7c，miR-99a，miR-17，miR-143和miR-转移性大肠癌（mCRC）患者为145。