Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age.

中文翻译：

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乳头状甲状腺癌中的拷贝数改变：SESN2的丢失是否在与年龄有关的不同预后中起作用？

甲状腺癌是唯一将年龄作为重要预后因素的肿瘤。在甲状腺乳头状癌（PTC）中，45岁似乎是将成年患者分为两组的关键点，两组患者具有不同的临床特征。该研究的目的是对两组患者（<45岁和≥45岁）进行基于微阵列的分析，以验证可能与不同患者行为相关的特定拷贝数改变（CNA）的发生与年龄有关。