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Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of SESN2 Have a Role in Age-related Different Prognoses?
Cancer Genomics & Proteomics ( IF 2.6 ) Pub Date : 2020-8-30 , DOI: 10.21873/cgp.20220
Deise Cibele N DE Almeida 1 , Michel Platini Caldas DE Souza 2 , Carolina Koury Nassar Amorim 3 , Jersey Heitor DA Silva MauÉs 4 , Fernanda DO E Santo Sagica 3 , Caroline Aquino Moreira-Nunes 5 , Edivaldo Herculano C DE Oliveira 3, 6
Affiliation  

Thyroid cancer is the only tumor in which age is an important prognostic factor. In papillary thyroid carcinomas (PTC), 45 years of age seems to be a key point that divides adult patients into two groups, with different clinical features. The aim of the study was to perform a microarray-based analysis in two groups of patients (<45 and ≥45 years old), in order to verify the occurrence of specific copy number alterations (CNAs) that could be associated to different patient behaviors associated with age.

中文翻译:

乳头状甲状腺癌中的拷贝数改变:SESN2的丢失是否在与年龄有关的不同预后中起作用?

甲状腺癌是唯一将年龄作为重要预后因素的肿瘤。在甲状腺乳头状癌(PTC)中,45岁似乎是将成年患者分为两组的关键点,两组患者具有不同的临床特征。该研究的目的是对两组患者(<45岁和≥45岁)进行基于微阵列的分析,以验证可能与不同患者行为相关的特定拷贝数改变(CNA)的发生与年龄有关。
更新日期:2020-08-31
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