Electrochemical asymmetric synthesis of biologically active substances.,Organic & Biomolecular Chemistry

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Electrochemical asymmetric synthesis of biologically active substances.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0ob01425g
Ana Maria Faisca Phillips ₁ , Armando J L Pombeiro ₁

Affiliation

Electrically driven oxidation and reduction reactions are well-established methods for synthesis even in the chemical industry, but asymmetric versions are still few. The mild conditions used, atom efficiency and low cost make these reactions a very attractive alternative to other methods of synthesis. Very fine tuning can be achieved based on minute changes in potentials, allowing only one functional group in a molecule to react in the presence of several others, which is ideal for applications in total synthesis. In this review, the literature in the field of asymmetric synthesis of biologically active substances over the last 10 years is surveyed.

中文翻译：

生物活性物质的电化学不对称合成。

即使在化学工业中，电驱动的氧化和还原反应也是成熟的合成方法，但不对称版本仍然很少。所使用的温和条件、原子效率和低成本使这些反应成为其他合成方法的非常有吸引力的替代方法。可以根据电位的微小变化实现非常精细的调节，允许分子中仅一个官能团在其他几个官能团存在的情况下发生反应，这对于全合成应用来说是理想的。本文综述了近10年来生物活性物质不对称合成领域的文献。

更新日期：2020-09-23

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