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Atherogenic index of plasma is associated with the severity of Hidradenitis Suppurativa: a case-control study.
Lipids in Health and Disease ( IF 3.9 ) Pub Date : 2020-08-29 , DOI: 10.1186/s12944-020-01377-6
José L Hernández 1 , Cristina Baldeón 2 , Ana E López-Sundh 3 , J Gonzalo Ocejo-Vinyals 4 , Ricardo Blanco 5 , Marcos A González-López 6
Affiliation  

Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with several comorbidities and vascular risk factors, such as dyslipidemia. The present study aimed to assess the possible associations between the lipid profile and atherogenic indexes and the severity of HS. This case-control study enrolled 78 HS patients and 62 healthy controls. Classic lipid profile and lipoprotein ratios, including the atherogenic index of plasma (AIP), were evaluated. The severity of HS was measured by the HS Physician Global Assessment (PGA). HS-patients had lower serum total cholesterol and HDL-C levels and higher AIP than the control group. AIP was positively correlated to BMI, waist circumference, systolic and diastolic blood pressure, LDL-C, triglycerides, non-HDL-C, ApoB, HOMA, and hs-CRP and negatively to HDL-C and ApoA1. For the overall lipid profile, only AIP was related to a more severe HS (PGA ≥ 3) after controlling for age, sex, BMI, insulin resistance (IR), active smoking, and statin use (r = 0.268; p = 0.023). Multiple logistic regression adjusted for age, sex, BMI, IR, smoking status and statin use, showed that AIP ≥ 0.11 was significantly associated with the severity of HS (OR, 4.38; CI 95%, 1.09–17.50; p = 0.037). In conclusion, these results showed that AIP is significantly and independently associated with HS severity.

中文翻译:

血浆的致动脉粥样硬化指数与化脓性汗腺炎的严重程度相关:一项病例对照研究。

化脓性汗腺炎(HS)是一种慢性炎性疾病,与多种合并症和血管性危险因素(例如血脂异常)相关。本研究旨在评估脂质谱和动脉粥样硬化指数与HS严重程度之间的可能联系。这项病例对照研究招募了78名HS患者和62名健康对照。评价了经典的脂质谱和脂蛋白比率,包括血浆的动脉粥样硬化指数(AIP)。HS的严重程度通过HS医师全球评估(PGA)进行测量。HS患者的血清总胆固醇和HDL-C水平较低,AIP高于对照组。AIP与BMI,腰围,收缩压和舒张压,LDL-C,甘油三酸酯,非HDL-C,ApoB,HOMA和hs-CRP正相关,而与HDL-C和ApoA1负相关。对于总体脂质分布,在控制了年龄,性别,BMI,胰岛素抵抗(IR),积极吸烟和他汀类药物使用后,只有AIP与更严重的HS(PGA≥3)相关(r = 0.268; p = 0.023) 。校正了年龄,性别,BMI,IR,吸烟状况和他汀类药物使用后的多元logistic回归显示,AIP≥0.11与HS的严重程度显着相关(OR,4.38; CI 95%,1.09-17.50; p = 0.037)。总之,这些结果表明,AIP与HS严重程度显着且独立相关。11与HS的严重程度显着相关(OR,4.38; CI 95%,1.09–17.50; p = 0.037)。总之,这些结果表明,AIP与HS严重程度显着且独立相关。11与HS的严重程度显着相关(OR,4.38; CI 95%,1.09–17.50; p = 0.037)。总之,这些结果表明,AIP与HS严重程度显着且独立相关。
更新日期:2020-08-29
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