Palladium-Catalyzed Decarbonylative Heck Coupling of Aromatic Carboxylic Acids with Terminal Alkenes.,Organic Letters

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Palladium-Catalyzed Decarbonylative Heck Coupling of Aromatic Carboxylic Acids with Terminal Alkenes.
Organic Letters ( IF 4.9 ) Pub Date : 2020-08-28 , DOI: 10.1021/acs.orglett.0c02462
Wenqing Yu ₁ , Long Liu ₁ , Tianzeng Huang ₁ , Xiangbing Zhou ₁ , Tieqiao Chen ₁

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A palladium-catalyzed decarbonylative alkenylation of aromatic carboxylic acids was developed. Under the reaction conditions, various benzoic acids including those bearing functional groups coupled to terminal alkenes, producing the corresponding internal alkenes in good to high yields. Cinnamic acids and bioactive benzoic acids such as 3-methylflavone-8-carboxylic acid, probenecid, adapalin, and febuxostat were also applicable to this reaction, demonstrating the potential synthetic value of this new reaction in organic synthesis.

中文翻译：

钯催化的芳族羧酸与末端烯烃的脱羰基Heck偶联。

开发了钯催化的芳族羧酸的脱羰链烯基化反应。在反应条件下，包括带有官能团的那些苯甲酸在内的各种苯甲酸与末端烯烃偶联，以高至高收率生产相应的内部烯烃。肉桂酸和生物活性苯甲酸，例如3-甲基黄酮-8-羧酸，丙磺舒，阿达帕林和非布索坦也适用于该反应，证明了该新反应在有机合成中的潜在合成价值。

更新日期：2020-09-20

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