Recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and subsequent containment procedures have impacted the world as never seen before. Therefore, there is considerable curiosity about the genome evolution related to the origin, transmission and vaccine impact of this virus. We have analysed genome sequences of SARS-CoV-2 isolated from Indian patients to gain an in-depth understanding of genomic evolution and transmission in India. Phylogenetic analysis and mutation profiling revealed major lineages being evolved by characteristic mutations. As the mutation frequency in spike protein is comparatively lesser, the candidate vaccines expected to have wide coverage worldwide including India.


中文翻译：

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印度严重急性呼吸综合征冠状病毒2的基因组进化及疫苗影响。



最近出现的严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 和随后的遏制措施对世界产生了前所未有的影响。因此，人们对与这种病毒的起源、传播和疫苗影响相关的基因组进化充满好奇。我们分析了从印度患者身上分离出的 SARS-CoV-2 的基因组序列，以深入了解印度的基因组进化和传播。系统发育分析和突变分析揭示了主要谱系是由特征突变进化而来的。由于刺突蛋白的突变频率相对较低，候选疫苗有望在包括印度在内的全球范围内广泛覆盖。