Cryptococcosis is a fungal disease with worldwide distribution and wide array of clinical manifestations, caused by encapsulated basidiomycetous yeasts called Cryptococcus spp. It has traditionally been considered an opportunistic infection known to occur in immunocompromised hosts, particularly those who are infected with human immunodeficiency virus. However, this infection has also been reported in phenotypically 'normal' or otherwise clinically non-immunocompromised patients. The seemingly mysterious nature of this potentially fatal illness has always kept clinicians and diagnosticians in a dilemma. This case series reiterates this perspective.


中文翻译：

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非人类免疫缺陷病毒感染患者的隐球菌病：临床困境和诊断之谜。



隐球菌病是一种全球性分布、临床表现广泛的真菌病，由被称为隐球菌属的包囊担子菌酵母引起。传统上，它被认为是一种已知发生在免疫功能低下的宿主中的机会性感染，特别是感染人类免疫缺陷病毒的宿主。然而，在表型“正常”或临床上非免疫功能低下的患者中也有这种感染的报道。这种潜在致命疾病看似神秘的本质始终让临床医生和诊断医生陷入两难境地。本案例系列重申了这一观点。