Background. Migraine is a severe and debilitating neurologic disorder and is claimed to be the sixth disabling illness in the world. This study aimed to determine the overall prevalence of restless legs syndrome (RLS) in patients with migraine through a systematic review and meta-analysis. Methods. To identify and select related studies, the Scopus, ScienceDirect, Embase, SID, IranDoc, Web of Science, Knowledge Network System Medline (PubMed), and Google Scholar databases were searched. All related cross-sectional studies, published in English or Persian language between January 2000 and December 2019 and using the keywords such as migraine, restless leg syndrome, sleep disorder, RLS, and migraine disorder, were collected. The heterogeneity of the studies was assessed using the index, and the data analysis was performed using the Comprehensive Meta-Analysis software. Results. Analysis was conducted on the reported results of the final 12 articles with the total sample size of 15196. The overall prevalence of RLS in patients with migraine was 16.3% (95% CI: 12.6–20.8%). The prevalence of RLS migraine patients decreased with increasing the sample size, and the prevalence of RLS migraine patients increased with increasing the research year, which was statistically significant (). Conclusion. This study highlights that RLS is high in patients with migraine, and therefore, the clinicians should be aware of its incidence and take preventive measures.

中文翻译：

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偏头痛患者不安腿综合征的患病率：系统评价和荟萃分析。


背景。偏头痛是一种严重且使人衰弱的神经系统疾病，据称是世界上第六种致残疾病。本研究旨在通过系统评价和荟萃分析来确定偏头痛患者不宁腿综合征 (RLS) 的总体患病率。方法。为了识别和选择相关研究，我们检索了 Scopus、ScienceDirect、Embase、SID、IranDoc、Web of Science、Knowledge Network System Medline (PubMed) 和 Google Scholar 数据库。收集了 2000 年 1 月至 2019 年 12 月期间以英语或波斯语发表的所有相关横断面研究，并使用偏头痛、不宁腿综合征、睡眠障碍、不宁腿综合症和偏头痛障碍等关键词。使用该指数评估研究的异质性，并使用综合荟萃分析软件进行数据分析。结果。对最终 12 篇文章的报告结果进行分析，总样本量为 15196。偏头痛患者 RLS 的总体患病率为 16.3%（95% CI：12.6-20.8%）。随着样本量的增加，RLS偏头痛患者的患病率下降，随着研究年份的增加，RLS偏头痛患者的患病率增加，具有统计学意义（ ）。结论。这项研究强调，偏头痛患者的 RLS 发病率较高，因此临床医生应了解其发病率并采取预防措施。