Genomes are characterised by large regions of homogeneous base compositions known as isochores. The latter are divided into GC-poor and GC-rich classes linked to distinct functional and structural properties. Several studies have addressed how isochores shape function and structure. To aid in this important subject, we present IsoXpressor, a tool designed for the analysis of the functional property of transcription within isochores. IsoXpressor allows users to process RNA-seq data in relation to the isochores, and it can be employed to investigate any biological question of interest for any species. The results presented herein as proof of concept are focused on the pre-implantation process in Homo sapiens (human) and Macaca mulatta (rhesus monkey).

中文翻译：

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IsoXpressor：一种评估等时线内转录活性的工具。

基因组的特征是均质碱基组成的大区域，即等位基因。后者分为与不同的功能和结构特性相关的GC贫乏和GC富裕的​​类别。多项研究已经解决了等时线如何塑造功能和结构的问题。为了帮助完成这一重要主题，我们介绍了IsoXpressor，这是一种用于分析等位线内转录功能特性的工具。IsoXpressor允许用户处理与等时线有关的RNA-seq数据，并且可以用于调查任何物种感兴趣的任何生物学问题。本文提出的结果作为概念验证集中于智人（人）和猕猴（恒河猴）的植入前过程。