Radical‐Mediated Non‐Dearomative Strategies in Construction of Spiro Compounds,Advanced Synthesis & Catalysis

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Radical‐Mediated Non‐Dearomative Strategies in Construction of Spiro Compounds
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-08-28 , DOI: 10.1002/adsc.202000807
R. Pawlowski ₁ , P. Skorka ₂ , M. Stodulski ₁

Affiliation

In recent years, spirocyclic compounds have attracted a significant interest in medicinal chemistry due to their considerable biological activities. The general and widely used concept for spirocyclic compound synthesis is related with dearomatization of starting material. However, most of the libraries prepared using this concept comprise structure similarity. Therefore, preparation of structurally distinct libraries comprising varied functionality requires different approaches and that includes non‐dearomative pathways. In given review recent advance in the synthesis of structurally varied spirocycles via radical‐mediated non‐dearomative strategies is discussed. In this context, application of radical initiators or photoredox catalysis is described. The variety of the presented examples indicates the high potential of the visible‐light‐induced methodologies in spirocyclic compound synthesis, which can act as a very efficient green alternative to known procedures, offering mild reaction conditions and high functional group tolerance.

中文翻译：

螺环化合物构建中的自由基介导的非定律策略

近年来，螺环化合物由于其相当大的生物活性而引起了人们对药物化学的极大兴趣。螺环化合物合成的普遍且广泛使用的概念与原料的脱芳香化有关。但是，使用此概念准备的大多数库都包含结构相似性。因此，制备具有不同功能的结构上不同的文库需要不同的方法，其中包括非竞争性途径。在给定的综述中，通过结构合成螺环的最新进展讨论了激进介导的非代议策略。在本文中，描述了自由基引发剂或光氧化还原催化的应用。所提供的各种实例表明，可见光诱导的方法在螺环化合物合成中具有很高的潜力，可以作为已知方法的非常有效的绿色替代方法，提供温和的反应条件和较高的官能团耐受性。

更新日期：2020-11-04

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