Cerebrovascular reactivity (CVR) is a specific indicator of autoregulatory efficiency. Studies have demonstrated that CVR depends on the baseline vascular dilation status between groups. Within the brain, there also exist spatial variations in both the resting cerebral blood flow (CBF) and CVR across different cerebral regions. However, the relationship between the regional CBF and CVR remains unclear. Hence, the primary goal of this study was to investigate the relationship between the resting CBF using pseudocontinuous arterial spin labeling (pCASL) technique and CVR using blood oxygenation level‐dependent (BOLD) technique across different cerebral regions. Eleven male and 14 female young volunteers were recruited in this study. Each subject was asked to perform the breath‐holding challenge to evaluate CVR at 3 T. The resting CBF was measured using pCASL in each subject. The relationships between CBF and CVR across the lobes were evaluated using the Spearman's rank test. The results showed that, for both sexes, the frontal lobe had the maximal resting perfusion but minimal vascular response to hypercapnia, whereas the occipital lobe had the lowest baseline CBF but maximal reactivity to hypercapnia, suggesting low and high autoregulatory efficiencies at high and low resting CBF in the brain, respectively. Sex‐related differences were observed in CBF but not in CVR. These findings may be of clinical interest in the assessment of cerebrovascular reserve and regional‐dependent vascular diseases.

中文翻译：

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使用BOLD fMRI表征屏气对屏气的脑血管区域差异

脑血管反应性（CVR）是自动调节效率的特定指标。研究表明，CVR取决于各组之间的基线血管扩张状态。在大脑内，不同大脑区域的静息脑血流量（CBF）和CVR均存在空间变化。但是，地区脑血流和心脑血管之间的关系仍不清楚。因此，本研究的主要目的是研究在不同大脑区域使用伪连续动脉自旋标记（pCASL）技术的静息CBF与使用血液氧合水平依赖性（BOLD）技术的CVR之间的关系。这项研究招募了11名男性和14名女性年轻志愿者。要求每个受试者进行屏气挑战以评估3 T时的CVR。使用pCASL在每个受试者中测量静息CBF。使用Spearman秩检验评估了跨叶的CBF和CVR之间的关系。结果表明，对于男女来说，额叶的静息灌注量最大，而对高碳酸血症的血管反应最小，而枕叶的基线CBF最低，但对高碳酸血症的反应性最大，表明高静息状态下的自调节效率低和高大脑中的CBF分别。在CBF中观察到性别相关差异，但在CVR中未观察到。这些发现可能在评估脑血管储备和区域依赖性血管疾病方面具有临床意义。对于男女来说，额叶的静息灌注量最大，但对高碳酸血症的血管反应最小，而枕叶的基线CBF最低，但对高碳酸血症的反应性最大，这表明在高静息CBF和低静息CBF时，自动调节效率低下和高，分别。在CBF中观察到性别相关差异，但在CVR中未观察到。这些发现可能在评估脑血管储备和区域依赖性血管疾病方面具有临床意义。对于男女来说，额叶的静息灌注量最大，而对高碳酸血症的血管反应最小，而枕叶的基线CBF最低，但对高碳酸血症的反应性最大，这表明在高静息CBF和低静息CBF时，自调节效率低下和高分别。在CBF中观察到性别相关差异，但在CVR中未观察到。这些发现可能在评估脑血管储备和区域依赖性血管疾病方面具有临床意义。在CBF中观察到性别相关差异，但在CVR中未观察到。这些发现可能在评估脑血管储备和区域依赖性血管疾病方面具有临床意义。在CBF中观察到性别相关差异，但在CVR中未观察到。这些发现可能在评估脑血管储备和区域依赖性血管疾病方面具有临床意义。