Multiwalled carbon nanotubes crowned with nickel‐ferrite magnetic nanoparticles assisted heterogeneous catalytic strategy for the synthesis of benzo[d]imidazo[2,1‐b]thiazole scaffolds,Journal of Heterocyclic Chemistry

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Multiwalled carbon nanotubes crowned with nickel‐ferrite magnetic nanoparticles assisted heterogeneous catalytic strategy for the synthesis of benzo[d]imidazo[2,1‐b]thiazole scaffolds
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-08-29 , DOI: 10.1002/jhet.4140
Deepika Geedkar ₁ , Ashok Kumar ₁ , Pratibha Sharma ₁

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Present manuscript elicits an account of the sonication promoted multicomponent reactions strategy assisted by multiwalled carbon nanotubes embraced with nickel‐ferrite (NiFe₂O₄‐CNTs) magnetic nanoparticles, as a heterogeneous catalyst to synthesize a novel series of pharmacologically active benzo[d]imidazo[2,1‐b]thiazole scaffolds. The synthesis of these biologically active derivatives was achieved via. A³ coupling involving 2‐aminobenzothiazole, pertinent aryl aldehydes and phenyl acetylene derivatives, proceeded in PEG 400 as green solvent under aerobic conditions to afford the products in good to excellent yields. The higher environmental compatibility and sustainability factors such as higher ecoscale score, smaller E‐factor and appreciable atom economy put this etiquette under the parasol of green chemistry precepts. The characterization of synthesized catalysts was attained through varied techniques viz. powder X‐ray diffraction, field emission scanning electron microscopy with energy‐dispersive X‐ray spectroscopy, Raman, FT‐IR, VSM and TGA‐DTA‐DTG analyses, dispersion studies, and nitrogen porosimetry analyses. The structures of the synthesized compounds were also endorsed by extensive spectroscopic studies (FT‐IR, ¹H and ¹³C NMR, Mass) and elemental analyses.

中文翻译：

冠状镍铁氧体磁性纳米粒子冠冕的多壁碳纳米管辅助多相催化策略合成苯并[d]咪唑并[2,1-b]噻唑支架

本手稿解释了超声促进多组分反应的策略，该策略由多壁碳纳米管与镍铁氧体（NiFe ₂ O ₄ -CNTs）磁性纳米粒子组成，作为多相催化剂合成一系列具有药理活性的新型苯并[ d ]咪唑[2,1- b ]噻唑支架。这些生物活性衍生物的合成是通过。A ³在有氧条件下，在PEG 400中作为绿色溶剂，进行了涉及2-氨基苯并噻唑，相关的芳基醛和苯基乙炔衍生物的偶联反应，以良好的产率获得了优异的产品。较高的环境相容性和可持续性因素，例如较高的生态规模得分，较小的E因子和可观的原子经济性，使该礼节成为绿色化学准则的遮阳伞。合成催化剂的表征是通过多种技术获得的。粉末X射线衍射，具有能量色散X射线光谱学的场发射扫描电子显微镜，拉曼光谱，FT-IR，VSM和TGA-DTA-DTG分析，色散研究和氮气孔隙率分析。广泛的光谱学研究也证实了合成化合物的结构（FT‐IR，¹H和¹³ C NMR，质量）和元素分析。

更新日期：2020-08-29

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