Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review,Annals of the New York Academy of Sciences

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Transmission of SARS‐CoV‐2 through breast milk and breastfeeding: a living systematic review
Annals of the New York Academy of Sciences ( IF 4.1 ) Pub Date : 2020-08-28 , DOI: 10.1111/nyas.14477
Elizabeth Centeno-Tablante ₁ , Melisa Medina-Rivera ₁ , Julia L Finkelstein ₁ , Pura Rayco-Solon ₂ , Maria Nieves Garcia-Casal ₃ , Lisa Rogers ₃ , Kate Ghezzi-Kopel ₄ , Pratiwi Ridwan ₁ , Juan Pablo Peña-Rosas ₃ , Saurabh Mehta ₁

Affiliation

The pandemic of coronavirus disease 2019 (COVID‐19) is caused by infection with a novel coronavirus strain, the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). At present, there is limited information on potential transmission of the infection from mother to child, particularly through breast milk and breastfeeding. Here, we provide a living systematic review to capture information that might necessitate changes in the guidance on breast milk and breastfeeding given the uncertainty in this area. Our search retrieved 19,414 total records; 605 were considered for full‐text eligibility and no ongoing trials were identified. Our review includes 340 records, 37 with breast milk samples and 303 without. The 37 articles with analyzed breast milk samples reported on 77 mothers who were breastfeeding their children; among them, 19 of 77 children were confirmed COVID‐19 cases based on RT‐PCR assays, including 14 neonates and five older infants. Nine of the 68 analyzed breast milk samples from mothers with COVID‐19 were positive for SARS‐CoV‐2 RNA; of the exposed infants, four were positive and two were negative for COVID‐19. Currently, there is no evidence of SARS‐CoV‐2 transmission through breast milk. Studies are needed with longer follow‐up periods that collect data on infant feeding practices and on viral presence in breast milk.

中文翻译：

SARS-CoV-2 通过母乳和母乳喂养传播：实时系统评价

2019 年冠状病毒病 (COVID-19) 的大流行是由新型冠状病毒株——严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染引起的。目前，关于母婴感染的潜在传播（尤其是通过母乳和母乳喂养）的信息有限。在这里，我们提供了一个生动的系统回顾，以捕获鉴于该领域的不确定性而可能需要更改母乳和母乳喂养指南的信息。我们的搜索共检索到 19,414 条记录；605 项被考虑为全文资格，但没有确定正在进行的试验。我们的审查包括 340 条记录，其中 37 条有母乳样本，303 条没有母乳样本。37 篇分析母乳样本的文章报道了 77 名正在母乳喂养孩子的母亲；其中，根据 RT-PCR 检测，77 名儿童中有 19 名确诊为 COVID-19 病例，其中包括 14 名新生儿和 5 名较大婴儿。在分析的 68 份来自 COVID-19 母亲的母乳样本中，有 9 份的 SARS-CoV-2 RNA 呈阳性；在暴露的婴儿中，四名婴儿的 COVID-19 呈阳性，两名婴儿呈阴性。目前，没有证据表明 SARS-CoV-2 通过母乳传播。需要进行更长的随访期研究，收集有关婴儿喂养方式和母乳中病毒存在的数据。

更新日期：2020-08-28

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