Synthetic hydroxyapatite is a bioceramic material promising for medical applications. The introduction of substituents into the crystal structure of hydroxyapatite allows tailoring its properties and obtaining materials with improved implantation characteristics. In the present work, it was shown for the first time that silicate and strontium co-substituted hydroxyapatite can be synthesized via the “soft” mechanochemical method. The synthesis was carried out by subjecting the reaction mixture to ball milling in the absence of any organic surfactant or solvent. The product of the mechanochemical synthesis was a single-phase material with a nanocrystalline structure. The crystal structure of co-substituted hydroxyapatite Ca_9.5Sr_0.5(PO₄)_5.5(SiO₄)_0.5(OH)_1.5 was analyzed for the first time. The synthesized co-substituted hydroxyapatite does not require any further processing or treatment and can be used as a biomaterial in the as-synthesized state.

合成的羟基磷灰石是一种有望用于医疗应用的生物陶瓷材料。将取代基引入羟基磷灰石的晶体结构中可以调整其性质并获得具有改善的注入特性的材料。在本工作中，首次证明可以通过“软”机械化学方法合成硅酸盐和锶共取代的羟基磷灰石。通过在没有任何有机表面活性剂或溶剂的情况下使反应混合物进行球磨来进行合成。机械化学合成的产物是具有纳米晶体结构的单相材料。共取代羟基磷灰石Ca _9.5 Sr _0.5（PO ₄）_5.5的晶体结构首次分析了（SiO ₄）_0.5（OH）_1.5。合成的共取代羟基磷灰石不需要任何进一步的处理或处理，并且可以以合成后的状态用作生物材料。