This study aimed to evaluate the effects of certain grain medium conditions, such as carbon and nitrogen source addition, water content, and initial pH, on the hispidin production of Phellinus linteus using solid-state fermentation. The results showed that the highest hispidin yield, specific productivity of hispidin, and total content of hispidin were associated with sucrose and malt extract addition, 55% water content, and an initial pH of 5.5, which resulted in 0.290, 0.233, 0.301, and 0.296 mg/g dry weight of mycelium; 0.261, 0.191, 0.257, and 0.227 μg/mg week⁻¹ specific productivity; and 46.01, 40.67, 58.85, and 55.06 mg/kg dry weight brown rice medium, respectively. Additionally, two combinations of culture conditions with pearl barley and black rice medium were tested for hispidin production. The highest hispidin yield, specific productivity of hispidin, and total hispidin content for pearl barley medium fermented using P. linteus were 3.88-fold, 4.86-fold, and 3.60-fold higher than those for the control (brown rice medium), respectively. Overall, this study shows that P. linteus hispidin production can be enhanced using solid-state fermentation, with optimal medium conditions.

这项研究旨在评估某些谷物培养基条件（例如添加碳和氮源，水含量和初始pH）对使用固态发酵的桑黄组织素生产的影响。结果表明，最高的组蛋白产量，组蛋白的比生产率和组蛋白的总含量与蔗糖和麦芽提取物的添加，55％的水含量以及5.5的初始pH值相关，分别为0.290、0.233、0.301和0.296 mg / g菌丝干重；第^-1周的0.261、0.191、0.257和0.227μg/ mg比生产率；分别为46.01、40.67、58.85和55.06 mg / kg干重糙米培养基。另外，测试了用珍珠大麦和黑米培养基的两种培养条件的组合的组氨酸生产。使用P. linteus发酵的珍珠大麦培养基，最高的组蛋白产量，组蛋白的比生产率和组蛋白总含量分别比对照（糙米培养基）高3.88倍，4.86倍和3.60倍。总体而言，本研究表明，P.黄hispidin生产可使用固态发酵，具有最佳培养基条件来增强。