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Quercetin abrogates bisphenol A induced altered neurobehavioral response and oxidative stress in zebrafish by modulating brain antioxidant defence system.
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-08-29 , DOI: 10.1016/j.etap.2020.103483
Pradyumna Kumar Sahoo 1 , Lilesh Kumar Pradhan 1 , Sai Aparna 2 , Komal Agarwal 1 , Ankita Banerjee 1 , Saroj Kumar Das 1
Affiliation  

Bisphenol A (BPA), a well-recognized anthropogenic xenoestrogen, has been identified as a causative agent responsible for inducing carcinogenicity, cognitive impairment, neurotoxicity, oxidative stress, etc. However, BPA-induced neurotoxicity and its possible amelioration through natural compound intervention remain elusive. The current study was performed to elucidate the neurotoxic potential of BPA in zebrafish (Danio rerio) by waterborne exposure and its possible amelioration by quercetin co-supplementation. Protective effect of quercetin against BPA-induced altered neurobehavioral response, oxidative stress and neuromorphological changes were evaluated in zebrafish brain. The present findings reveal that BPA-induced altered neurobehavioral response was ameliorated by quercetin. Biochemical studies advocate the potential therapeutic efficacy of quercetin against BPA-induced oxidative stress in zebrafish brain. Quercetin also shows neuroprotection against BPA-induced augmented neuronal pyknosis in periventricular grey zone (PGZ) of zebrafish brain. These basic findings indicate that quercetin may act as an effective intervention against BPA-induced neurotoxicity in zebrafish through down-regulation of oxidative stress.



中文翻译:

槲皮素通过调节脑中的抗氧化剂防御系统,消除了双酚A诱导的斑马鱼神经行为改变和氧化应激反应。

双酚A(BPA)是一种公认​​的人为异种雌激素,已被确认为可引起致癌性,认知障碍,神经毒性,氧化应激等的原因。然而,BPA诱导的神经毒性及其通过天然化合​​物干预的可能的缓解作用仍然存在难以捉摸。目前的研究是为了阐明斑马鱼中BPA的神经毒性潜力(Danio rerio),以及通过槲皮素共同补充可改善其水溶性。在斑马鱼脑中评估槲皮素对双酚A诱导的神经行为改变,氧化应激和神经形态学变化的保护作用。目前的发现表明槲皮素改善了BPA诱导的神经行为改变。生化研究主张槲皮素对斑马鱼脑中BPA诱导的氧化应激的潜在治疗功效。槲皮素还显示出对BPA引起的斑马鱼脑室灰质区(PGZ)中BPA引起的神经元肥大症的神经保护作用。这些基本发现表明,槲皮素可能通过下调氧化应激作为对BPA引起的斑马鱼神经毒性的有效干预措施。

更新日期:2020-09-13
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