Purpose

To determine the relative contributions to perceived discomfort during contact lens wear of contact time with the lens and the time of day at which wear begins, using a wearing framework similar to that of regular users.

Methods

Twenty-three participants reported ocular discomfort using a 1–100 visual analogue rating scale, when prompted by email, during one day without contact lenses and on three other days while wearing soft contact lenses for twelve hours. Contact lens wear began at a different time on each day. The effect of start time on the change in discomfort during the wearing period was evaluated.

Results

The average (± 95 % CI) change in discomfort over 12 h without contact lenses was -0.3 ± 3.5. The corresponding values during contact lens wear were 23.5 ± 14.6 when starting wear before 8am, 16.8 ± 11.0 when starting between 8am & 10am and 22.7 ± 8.4 when starting after 10am. While the increased discomfort was significant irrespective of start time (p < 0.01), there were no statistically significant differences between start times (p = 0.98).

Conclusion

Discomfort during contact lens wear is associated with the length of time lenses are on-eye but not with the time of day when lenses are placed on-eye. This relationship is variable in the population and does not, of itself, explain why contact lenses become uncomfortable during wear. Active monitoring of participant compliance should be a consideration in all studies involving time critical responses.

中文翻译：

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隐形眼镜不适的时间考虑。

目的

使用与普通用户相似的佩戴框架，确定隐形眼镜佩戴期间与镜片接触时间和佩戴开始时间对感知不适的相对贡献。

方法

23 名参与者使用 1-100 视觉模拟评分量表报告眼部不适，当收到电子邮件提示时，在一天不戴隐形眼镜和其他三天戴软性隐形眼镜 12 小时。每天的不同时间开始佩戴隐形眼镜。评估开始时间对佩戴期间不适变化的影响。

结果

在不戴隐形眼镜的情况下，12 小时内不适的平均 (± 95 % CI) 变化为 -0.3 ± 3.5。佩戴隐形眼镜期间的相应值在上午 8 点之前开始佩戴时为 23.5±14.6，在上午 8 点和上午 10 点之间开始佩戴时为 16.8±11.0，而在上午 10 点之后开始佩戴时为 22.7±8.4。虽然不考虑开始时间，增加的不适感是显着的（p < 0.01），但开始时间之间没有统计学上的显着差异（p = 0.98）。

结论

配戴隐形眼镜时的不适与镜片戴在眼睛上的时间长短有关，但与一天中镜片戴在眼睛上的时间无关。这种关系在人群中是可变的，本身并不能解释为什么隐形眼镜在佩戴时会变得不舒服。在所有涉及时间关键反应的研究中，都应考虑积极监测参与者的依从性。