Activity and specificity studies of the new thermostable esterase EstDZ2.,Bioorganic Chemistry

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Activity and specificity studies of the new thermostable esterase EstDZ2.
Bioorganic Chemistry ( IF 4.5 ) Pub Date : 2020-08-29 , DOI: 10.1016/j.bioorg.2020.104214
Kamela Myrtollari ₁ , Nikolaos Katsoulakis ₁ , Dimitra Zarafeta ₂ , Ioannis V Pavlidis ₁ , Georgios Skretas ₂ , Ioulia Smonou ₁

Affiliation

In this paper, we study the activity and specificity of EstDZ2, a new thermostable carboxyl esterase of unknown function, which was isolated from a metagenome library from a Russian hot spring. The biocatalytic reaction employing EstDZ2 proved to be an efficient method for the hydrolysis of aryl p-, o- or m-substituted esters of butyric acid and esters of secondary alcohols. Docking studies revealed structural features of the enzyme that led to activity differences among the different substrates.

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