Abstract In the current research, two porous Co(II)-containing metal-organic frameworks (MOFs) whose chemical formulae can be teamed as [Co2(bptc)(H2O)2]·5DMA (1, H4bptc = biphenyl-3,3′,5,5′-tetracarboxylic acid) and [Co2(Hatta)2·(H2O)3]·3DMA (2, H4atta = 2′-amino-[1,1′:4′,1″-terphenyl]-3,3″,5,5″- tetracarboxylic acid) have been solvothermally synthesized by using two similar tetracarboxylic ligands and structurally characterized. The complex 2 with amino-functionalized pores could be used as recoverable heterogeneous catalytic agent for Knoevenagel condensation without solvents. The inhibitory activity of compounds on the scar tissue hyperplasia was evaluated and the related mechanism was discussed as well. First of all, the proliferation of the human hypertrophic scar fibroblasts was measured after indicated treatment was measured by CCK-8 assay. Next, the real time RT-PCR was applied to determine the activation power of the VEGF signaling pathway after using compounds.

中文翻译：

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两种基于 Co(II) 的金属有机骨架：催化 Knoevenagel 缩合反应和通过降低 VEGF 信号通路活性对瘢痕组织增生的抑制活性

摘要 在目前的研究中，两种多孔含 Co(II) 的金属有机骨架 (MOFs) 的化学式可组合为 [Co2(bptc)(H2O)2]·5DMA (1, H4bptc = biphenyl-3,3 ',5,5'-四羧酸)和[Co2(Hatta)2·(H2O)3]·3DMA (2, H4atta = 2'-氨基-[1,1':4',1"-三联苯]- 3,3",5,5"-四羧酸)已通过使用两个相似的四羧酸配体溶剂热合成并进行了结构表征。具有氨基官能化孔的配合物2可用作无溶剂Knoevenagel缩合的可回收多相催化剂。评价了化合物对瘢痕组织增生的抑制作用，并讨论了相关机制。首先，通过CCK-8测定测量指定治疗后人肥厚性瘢痕成纤维细胞的增殖。