Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-08-28 , DOI: 10.1007/s13659-020-00263-z Swapnali Chetia 1 , Gaurab Borah 1
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Δ9-tetrahydrocannabinol (THC) of cannabis is the main psychoactive component which is a global significant concern to human health. Evaluation on THC reported its drastic effect on the brain dopaminergic (DAergic) system stimulating mesolimbic DA containing neurons thereby increasing the level of striatal DA. Cannabidiol (CBD), with its anxiolytic and anti-psychotic property, is potent to ameliorate the THC-induced DAergic variations. Legal authorization of cannabis use and its analogs in most countries led to a drastic dispute in the elicitation of cannabis products. With a recent increase in cannabis-induced disorder rates, the present review highlighted the detrimental effects of THC and the effects of CBD on THC induced alterations in DA synthesis and release. Alongside the reported data, uses of cannabis as a therapeutic medium in a number of health complications are also being briefly reviewed. These evaluated reports led to an anticipation of additional research contradictory to the findings of THC and CBD activity in the brain DAergic system and their medical implementations as therapeutics.
Graphic Abstract
中文翻译：
Δ 9-四氢大麻酚毒性和大麻二酚对大脑多巴胺水平的验证：大麻口是心非的评估。
大麻中的Δ9-四氢大麻酚（THC）是主要的精神活性成分，是全球关注人类健康的重要成分。对 THC 的评估报告称，它对大脑多巴胺能 (DAergic) 系统具有显着影响，刺激含有 DA 的中脑边缘神经元，从而增加纹状体 DA 的水平。大麻二酚 (CBD) 具有抗焦虑和抗精神病特性，能够有效改善 THC 诱导的 DAergic 变异。大多数国家对大麻及其类似物使用的法律授权导致了大麻产品引发的激烈争议。随着最近大麻引起的疾病发生率的增加，本综述强调了 THC 的有害影响以及 CBD 对 THC 引起的 DA 合成和释放变化的影响。除了报告的数据外，还对大麻作为治疗多种健康并发症的媒介的用途进行了简要审查。这些评估报告导致了对大脑 DAergic 系统中 THC 和 CBD 活性及其作为治疗方法的医学实施的研究结果相矛盾的更多研究的预期。
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