Abstract

The search for molecular genetic markers of depression has been going on for more than two decades, and it began with molecular studies of the genes of the neurotransmitter systems, primarily serotonin and dopamine. However, for most genes, the results of such studies remain contradictory. In the last decade, a new approach has been used to study the genetics of multifactorial diseases—a genome-wide search for associations. This method made it possible to supplement the list of potential genetic risk factors for depression with new genes that require additional research. The review describes two different approaches to the study of the genetics of depression, as well as current problems and recent advances in this field.

中文翻译：

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抑郁症的遗传学：候选基因和全基因组关联研究

摘要

寻找抑郁症的分子遗传标志物已经进行了二十多年，它始于对神经递质系统基因（主要是血清素和多巴胺）基因的分子研究。但是，对于大多数基因而言，此类研究的结果仍然是矛盾的。在过去的十年中，一种新的方法已用于研究多因素疾病的遗传学-在全基因组范围内寻找关联。这种方法有可能用需要进一步研究的新基因补充抑郁症的潜在遗传危险因素。这篇综述描述了研究抑郁症遗传学的两种不同方法，以及该领域的当前问题和最新进展。