The aim of the present study was to investigate the association of COPD and frequent exacerbator COPD phenotype with CRP, CD14, and pro-inflammatory cytokines and their receptors (TNFA, LTA, TNFRSF1A, TNFRSF1B, IL1B, and IL6) genes. It was found that COPD was associated with allele A of the TNFA gene (rs1800629G>A) (P = 0.002, OR = 1.45); the association was established in the log-additive model (P = 0.0022, P_cor-FDR = 0.01705, OR = 1.47); this association was confirmed in the frequent exacerbator COPD phenotype group (P = 0.001, P_cor-FDR = 0.007, OR = 1.59). Allele G of the LTA gene (rs909253A>G) (P = 0.002, OR = 1.33) was also shown to be a marker for COPD risk; the association was established in the log-additive model (P = 0.0021, P_cor-FDR = 0.01705, OR = 1.31) and it was confirmed in patients with rare exacerbations (P = 0.003, P_cor-FDR = 0.0084, OR = 1.39). The genotype GG of the TNFRSF1B gene (rs1061622T>G) was a marker of resistance to the development of the frequent exacerbator COPD phenotype (P = 0.003, P_cor-FDR = 0.0084, OR = 0.46). The genotype CC of the CD14 gene (rs2569190T>C) was associated with higher forced expiratory volume in 1 s (P = 0.006); subjects with genotype AA of the TNFRSF1B gene (rs1061624A >G) and genotype GG of the LTA gene (rs909253A>G) exhibited lower forced expiratory volume in 1 s (P = 0.04 and P = 0.01, respectively). Genotype AA of the TNFRSF1A gene (rs767455A>G) was associated with higher smoking pack-years (P = 0.0036).

中文翻译：

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CRP，CD14，促炎性细胞因子及其受体（TNFA，LTA，TNFRSF1A，TNFRSF1B，IL1B和IL6）基因与慢性阻塞性肺疾病发展的关联

本研究的目的是调查慢性阻塞性肺病协会和频繁exacerbator COPD表型与CRP，CD14和促炎细胞因子及其受体（TNFA，LTA，TNFRSF1A，TNFRSF1B，IL1B和IL6）基因。据发现，COPD与等位基因相关联甲所述的TNFA基因（rs1800629G> A）（P = 0.002，OR = 1.45）; 在对数加法模型中建立了关联（P = 0.0022，P _cor-FDR= 0.01705，或= 1.47）；这种关联在频繁发作的COPD表型组中得到了证实（P = 0.001，P _cor-FDR = 0.007，OR = 1.59）。等位基因G ^所述的LTA基因（rs909253A> G）（P = 0.002，OR = 1.33）也证明是COPD风险的标志物; 在对数加法模型中建立了关联（P = 0.0021，P _cor-FDR = 0.01705，OR = 1.31），并已在罕见急性发作患者中得到证实（P = 0.003，P _cor-FDR = 0.0084，OR = 1.39） ）。基因型GG的的TNFRSF1B该基因（rs1061622T> G）是对频繁发作的COPD表型发展的抗性标记（P = 0.003，P _cor-FDR = 0.0084，OR = 0.46）。基因型CC的的CD14（rs2569190T> C）基因在1秒（强迫更高呼气量相关联的P = 0.006）; 基因型受试者AA的的TNFRSF1B基因（rs1061624A> G）和基因型GG所述的LTA基因（rs909253A> G）在1秒（表现出较低的用力呼气量P = 0.04和P = 0.01）。基因型AA的的TNFRSF1A基因（rs767455A> G）与更高的吸烟年数相关（P = 0.0036）。