Structured hydrogels with thermo-sensitivity properties to be used as a novel carrier for controlled drug delivery were prepared here. These hydrogels were formed by core-shell particles, where the core is a semi-interpenetrated polymer network (semi-IPN) made of n-isopropylacrylamide (NIPAAm) and poly (ethylene glycol) (PEG), and a chitosan shell. All polymers were synthesized by using semi-continuous heterophase polymerization at different dosing rates to study their effect on particle size, system stability and drug deliver efficiency. Structural (FTIR, particle size, SEM) and functional analysis were performed (stability and drug delivery). FTIR confirmed the polymerization by showing the development of interactions between the characteristic functional groups from the polymers. SEM micrographs from hydrogels revealed a porous structure, which is affected by the dosing rate during the polymerization process as well as the particle size which affect the stability of the obtained latex. Drug release analysis of the hydrogels was performed into distilled water and in a buffer at different temperatures. Results shown that most of the characteristics of this polymer system can be controlled, and so tuning the controlled release behaviour, these findings made these hydrogels an important contender for controlled drug delivery. Graphical abstract Graphical abstract

中文翻译：

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基于聚（乙二醇）、正异丙基丙烯酰胺和壳聚糖的聚合物体系用于控制给药的性能研究

这里制备了具有热敏特性的结构化水凝胶，用作控制药物递送的新型载体。这些水凝胶由核壳颗粒形成，其中核是由正异丙基丙烯酰胺 (NIPAAm) 和聚乙二醇 (PEG) 制成的半互穿聚合物网络 (semi-IPN) 和壳聚糖壳。所有聚合物都是通过使用不同剂量率的半连续多相聚合来合成的，以研究它们对粒径、系统稳定性和药物递送效率的影响。进行了结构（FTIR、粒径、SEM）和功能分析（稳定性和药物递送）。FTIR 通过显示聚合物特征官能团之间相互作用的发展来证实聚合。水凝胶的 SEM 显微照片显示出多孔结构，这受聚合过程中的加料速率以及影响所得胶乳稳定性的粒径的影响。水凝胶的药物释放分析在蒸馏水和不同温度的缓冲液中进行。结果表明，该聚合物系统的大部分特性都是可以控制的，因此可以调整控释行为，这些发现使这些水凝胶成为控制药物递送的重要竞争者。图形摘要图形摘要 结果表明，该聚合物系统的大部分特性都是可以控制的，因此可以调整控释行为，这些发现使这些水凝胶成为控制药物递送的重要竞争者。图形摘要图形摘要 结果表明，该聚合物系统的大部分特性都是可以控制的，因此可以调整控释行为，这些发现使这些水凝胶成为控制药物递送的重要竞争者。图形摘要图形摘要