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Fabrication and characterization of lignin-xylan hybrid nanospheres as pesticide carriers with enzyme-mediated release property.
Soft Matter ( IF 2.9 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0sm01402h Yuehan Jiang 1 , Yiyi Chen 1 , Dong Tian 1 , Feiyue Shen 1 , Xue Wan 1 , Lu Xu 1 , Yichu Chen 1 , Haozhe Zhang 1 , Jinguang Hu 2 , Fei Shen 1
Soft Matter ( IF 2.9 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0sm01402h Yuehan Jiang 1 , Yiyi Chen 1 , Dong Tian 1 , Feiyue Shen 1 , Xue Wan 1 , Lu Xu 1 , Yichu Chen 1 , Haozhe Zhang 1 , Jinguang Hu 2 , Fei Shen 1
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Lignin nanospheres (LNPs) are an emerging high-value material platform to realize lignin valorization. The modification or introduction of new functions to LNPs is of great significance to expand its downstream applications. This work evaluated the technical feasibility of preparing lignin–xylan hybrid nanospheres (LXNPs) through a simple solution-based self-assembly process, with the goal of achieving the application as pesticide carriers for enzyme-mediated controlled release. Hybrid LXNPs with various weigh ratios (lignin to xylan, 3 : 1, 1 : 1, 1 : 3) were obtained using deep eutectic solvent-extracted condensed lignin and water-insoluble xylan fragments, which exhibited a nanosphere size of about 166–210 nm with considerable stability in the pH range of 4–10. LXNPs with lignin to xylan ratios of 3 : 1 and 1 : 1 showed well-defined core–shell structures with enriched hydroxyl groups on the surface. It was proposed that lignin could anchor xylan fragments through van der Waals force and hydrophobic interactions between lignin phenylpropanes and xylan molecular backbones, thus facilitating the self-assembly process for the formation of this specific spherical structure. The resulting hydrophobic LXNPs core enabled the facile encapsulation of the biological pesticide avermectin (AVM) with 57.9–67.0% efficiency using one-pot synthesis. When these AVM-encapsulated LXNPs were subjected to enzymatic hydrolysis using xylanase, considerable AVM release of 44.8–55.1% was achieved after 16 h, in comparison to the 4.1% release only for those without xylanase. This work showed the high promise of fabricating hybrid LXNPs through the self-assembly process and also provided a universal nanosphere carrier for drug encapsulation and subsequent enzyme-mediated controlled release.
中文翻译：
具有酶介导释放特性的木质素-木聚糖杂化纳米球作为农药载体的制备和表征。
木质素纳米球（LNP）是一种新兴的高价值材料平台，可实现木质素增值。对LNP进行改造或引入新功能对于拓展其下游应用具有重要意义。这项工作评估了通过简单的基于溶液的自组装过程制备木质素-木聚糖杂化纳米球（LXNP）的技术可行性，目标是实现作为酶介导控释农药载体的应用。使用低共熔溶剂萃取缩合木质素和水不溶性木聚糖片段获得了不同重量比（木质素与木聚糖，3:1、1:1、1:3）的杂化LXNP，其纳米球尺寸约为166-210 nm 在 4-10 的 pH 范围内具有相当的稳定性。木质素与木聚糖比例为 3:1 和 1:1 的 LXNPs 显示出明确的核壳结构，表面具有丰富的羟基。有人提出，木质素可以通过范德华力和木质素苯丙烷与木聚糖分子主链之间的疏水相互作用来锚定木聚糖片段，从而促进形成这种特定球形结构的自组装过程。由此产生的疏水性 LXNPs 核心能够通过一锅合成轻松封装生物农药阿维菌素 (AVM)，效率为 57.9–67.0%。当这些 AVM 封装的 LXNP 使用木聚糖酶进行酶水解时，16 小时后 AVM 释放量达到 44.8-55.1%，而没有木聚糖酶的 LXNP 释放量为 4.1%。这项工作展示了通过自组装过程制造杂化 LXNP 的巨大前景，并为药物封装和随后的酶介导的控制释放提供了通用的纳米球载体。
更新日期：2020-10-15
中文翻译：
具有酶介导释放特性的木质素-木聚糖杂化纳米球作为农药载体的制备和表征。
木质素纳米球（LNP）是一种新兴的高价值材料平台，可实现木质素增值。对LNP进行改造或引入新功能对于拓展其下游应用具有重要意义。这项工作评估了通过简单的基于溶液的自组装过程制备木质素-木聚糖杂化纳米球（LXNP）的技术可行性，目标是实现作为酶介导控释农药载体的应用。使用低共熔溶剂萃取缩合木质素和水不溶性木聚糖片段获得了不同重量比（木质素与木聚糖，3:1、1:1、1:3）的杂化LXNP，其纳米球尺寸约为166-210 nm 在 4-10 的 pH 范围内具有相当的稳定性。木质素与木聚糖比例为 3:1 和 1:1 的 LXNPs 显示出明确的核壳结构，表面具有丰富的羟基。有人提出，木质素可以通过范德华力和木质素苯丙烷与木聚糖分子主链之间的疏水相互作用来锚定木聚糖片段，从而促进形成这种特定球形结构的自组装过程。由此产生的疏水性 LXNPs 核心能够通过一锅合成轻松封装生物农药阿维菌素 (AVM)，效率为 57.9–67.0%。当这些 AVM 封装的 LXNP 使用木聚糖酶进行酶水解时，16 小时后 AVM 释放量达到 44.8-55.1%，而没有木聚糖酶的 LXNP 释放量为 4.1%。这项工作展示了通过自组装过程制造杂化 LXNP 的巨大前景，并为药物封装和随后的酶介导的控制释放提供了通用的纳米球载体。
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