Copper-catalyzed aerobic oxidative C-C bond cleavage of simple ketones for the synthesis of amides.,Organic & Biomolecular Chemistry

当前位置： X-MOL 学术 › Org. Biomol. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Copper-catalyzed aerobic oxidative C-C bond cleavage of simple ketones for the synthesis of amides.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0ob01601b
Guo-Ping Yang ₁ , Ke Li , Wei Liu , Kai Zeng , Yu-Feng Liu

Affiliation

A Cu-catalyzed oxidative amidation of simple ketones with amines via carbon–carbon (C–C) bond cleavage has been developed. A number of aryl and alkyl ketones could be easily converted to amides using cheap copper salt as the catalyst and O₂ as the oxidant with a wide range of amines, including primary and secondary amines. This method shows a notable advantage of the broad scope for the substrate, thus providing a practical approach to amides. A plausible mechanism is proposed based on the preliminary experiments.

中文翻译：

铜催化的简单酮的需氧氧化CC键裂解，用于合成酰胺。

已经开发了通过碳-碳（CC）键裂解的铜催化的简单酮与胺的氧化酰胺化方法。使用廉价的铜盐作为催化剂，O ₂作为氧化剂与多种胺，包括伯胺和仲胺，可以很容易地将许多芳基和烷基酮转化为酰胺。该方法显示出广泛的底物优势，因此为酰胺提供了一种实用的方法。在初步实验的基础上提出了一个合理的机制。

更新日期：2020-09-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11