Transport of nanoprobes in multicellular spheroids,Nanoscale

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Transport of nanoprobes in multicellular spheroids
Nanoscale ( IF 5.8 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0nr01986k
Marta Pilz _{1,

2,

3,

4,

5} , Karina Kwapiszewska _{1,

2,

3,

4,

5} , Tomasz Kalwarczyk _{1,

2,

3,

4,

5} , Grzegorz Bubak _{1,

2,

3,

4,

5} , Dominika Nowis _{4,

5,

6,

7,

8} , Robert Hołyst _{1,

2,

3,

4,

5}

Affiliation

The efficient delivery of drugs to cells depends on their diffusion through the extracellular matrix (ECM) of tissues. Here we present a study on the diffusion of nanoprobes of radius from 1 nm to over 100 nm in the ECM of spheroids of three cell types (HeLa, MCF-7 and fibroblasts). We quantified the nanoparticle transport in the spheroids’ proliferating zone. We determined the size-dependent viscosity of the ECM. We revealed that nanoobjects up to 10 nm in radius exhibited unobstructed diffusion in the ECM, regardless of the spheroid type. The presented length-scale dependent viscosity profiles for spheroids pave the way for advanced modelling of drug administration through tissues.

中文翻译：

纳米探针在多细胞球体中的运输

药物向细胞的有效递送取决于它们通过组织的细胞外基质（ECM）的扩散。在此，我们对三种细胞类型（HeLa，MCF-7和成纤维细胞）的类球体的ECM中半径从1 nm到100 nm以上的纳米探针的扩散进行了研究。我们量化了球体扩散区中的纳米颗粒运输。我们确定了ECM的尺寸依赖性粘度。我们发现，无论球体类型如何，半径最大10 nm的纳米物体在ECM中均表现出无阻碍的扩散。所呈现的球体的取决于长度尺度的粘度曲线为通过组织进行药物给药的高级建模铺平了道路。

更新日期：2020-10-08

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