Extraordinary optical, electrical and chemical properties of 2D materials have potential to be useful for quick and sensitive detection of pathological diseases. One important example is malaria disease that can progress rapidly and cause death within days. Therefore, fast, accurate and cost-effective malaria diagnosis available at the point of care is urgently needed to facilitate precise treatment. Here we report rapid and highly sensitive malaria detection with an inexpensive graphene-protected copper surface plasmon resonance biosensor. Using phase sensitive surface plasmon resonance technique and a graphene functionalization protocol for attaching end-tethered DNA probes that were complementary to a malaria specific DNA target, we were able to significantly improve the detection limit of the malarial plasmodium parasite. The phase sensitivity of our graphene-enhanced sensors exceeds by two orders of magnitude the sensitivity of analogous optical biosensors. This enhanced se...

中文翻译：

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石墨烯增强的表面等离子体激元共振用于疟疾的超灵敏和快速检测

2D材料的非凡光学，电学和化学性质可能对快速，灵敏地检测病理疾病有用。一个重要的例子是疟疾，这种疾病可以迅速发展并在数天内导致死亡。因此，迫切需要在护理点进行快速，准确和具有成本效益的疟疾诊断，以促进精确治疗。在这里，我们报告了使用廉价的石墨烯保护的铜表面等离子体共振生物传感器进行快速，高度灵敏的疟疾检测。使用相敏感的表面等离振子共振技术和石墨烯功能化方案来连接与疟疾特异的DNA靶互补的末端拴系DNA探针，我们能够显着提高疟疾疟原虫寄生虫的检测限。我们的石墨烯增强型传感器的相位灵敏度比类似的光学生物传感器的灵敏度高两个数量级。这个增强的功能...