Background The zebrafish is the system of choice in developmental biology and genetics in the recent years. Zebrafish genetics is improving, and this opens up new ways to understand genetic mechanisms. The zebrafish ( Danio rerio ) is used for investigation of developmental pathways and neurobiology because of its progression and physiological resemblance to humans. This species strikes stability between the sophistication as a vertebrate and its ease to be used as a model organism. In addition to this, the optical transparency of the developing fish together with novel imaging techniques enables a potent visualization of complex mechanisms at the level of the whole organism. Methods This review comprises information regarding zebrafish and its potent use as a model organism to study neurological disorders. The literature was collected from articles published in MEDLINE, SCOPUS, and PUBMED from 1974 to 2018. Results This review highlights the applications of Danio rerio in major neuropsychiatric disorders. It paves way to understand the biochemical and molecular pathways that infer in the neuropsychiatric disorders. Conclusion The present review discuss the significance of zebrafish as an animal model to study neurological disorders and to demonstrate the behavioural features observed which may be a precursor of a new loom for drug development.

中文翻译：

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斑马鱼作为神经精神病学研究的一个惊人工具

背景斑马鱼是近年来发育生物学和遗传学的首选系统。斑马鱼遗传学正在改进，这为了解遗传机制开辟了新途径。斑马鱼 ( Danio rerio ) 由于其进展和生理与人类的相似性而被用于研究发育途径和神经生物学。该物种在作为脊椎动物的复杂性和易于用作模式生物之间取得了稳定性。除此之外，发育中的鱼的光学透明度以及新的成像技术能够在整个生物体的水平上对复杂机制进行有效的可视化。方法 本综述包含有关斑马鱼及其作为研究神经系统疾病的模式生物的有效用途的信息。文献收集自 1974 年至 2018 年发表在 MEDLINE、SCOPUS 和 PUBMED 上的文章。 结果 本综述重点介绍了 Danio rerio 在主要神经精神疾病中的应用。它为了解推断神经精神疾病的生化和分子途径铺平了道路。结论 本综述讨论了斑马鱼作为研究神经系统疾病和证明观察到的行为特征的动物模型的重要性，这可能是药物开发新织机的先驱。