Novel pulsed-Doppler methods for perfusion imaging are validated using dialysis cartridges as perfusion phantoms. Techniques that were demonstrated qualitatively at 24 MHz, in vivo , are here examined quantitatively at 5 and 12.5 MHz using phantoms with the blood-mimicking fluid flow within cellulose microfibers. One goal is to explore a variety of flow states to optimize measurement sensitivity and flow accuracy. The results show that 2–3-s echo acquisitions at roughly 10 frames/s yield the highest sensitivity to flows of 1–4 mL/min. A second goal is to examine methods for setting the parameters of higher order singular value decomposition (HOSVD) clutter filters. For stationary or moving clutter, the velocity of the blood-mimicking fluid in the microfibers is consistently estimated within measurement uncertainty (mean coefficient of variation = 0.26). Power Doppler signals were equivalent for stationary and moving clutter after clutter filtering, increasing approximately 3 dB/mL/min of blood-mimicking fluid flow for $0\leq {q}\leq 4$ mL/min. Comparisons between phantom and preclinical images show that peripheral perfusion imaging can be reliably achieved without contrast enhancement.

中文翻译：

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HOSVD杂波滤波器对灌注成像的实验验证

使用透析盒作为灌注体模验证了用于灌注成像的新型脉冲多普勒方法。在24 MHz上定性展示的技术，体内 在此，使用幻象在5和12.5 MHz处定量模拟纤维素微纤维内的血液模拟流体。一个目标是探索各种流量状态，以优化测量灵敏度和流量精度。结果表明，以大约10帧/秒的速度捕获2至3秒回波，对1至4 mL / min的流量具有最高的灵敏度。第二个目标是研究用于设置高阶奇异值分解（HOSVD）杂波滤波器的参数的方法。对于静止或运动的杂波，在测量不确定性（均值变异系数= 0.26）内始终估算超细纤维中模拟血液的流体的速度。杂波滤波后，静态和运动杂波的功率多普勒信号均相等，从而使模拟血液的血流增加约3 dB / mL / min， $ 0 \ leq {q} \ leq 4 $ 毫升/分钟 体模图像和临床前图像之间的比较表明，无需增强对比度即可可靠地实现外周血流灌注成像。