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Recent advances in the development of anti-infective peptoids.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0cc04704j Kevin L Bicker 1 , Steven L Cobb 2
Chemical Communications ( IF 4.3 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0cc04704j Kevin L Bicker 1 , Steven L Cobb 2
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In the search for new sources of antimicrobials many researchers have investigated antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics. However, efforts to develop AMPs in this area has been severely hampered by their inherent susceptibility to enzymatic degradation. Given this only a handful of AMPs are currently in clinical trials. Peptide mimetics such as peptoids have emerged as highly promising alternatives to AMPs as they are inherently stable to enzymatic degradation and display potent antimicrobial properties. This feature article highlights the progress that has been made towards the development of novel anti-infective peptoids.
中文翻译：
抗感染类肽研究的最新进展。
在寻找抗菌素的新来源时，许多研究人员已经研究了抗菌肽（AMP）作为设计创新疗法的模板。然而，由于其固有的对酶促降解的敏感性，严重阻碍了在该领域开发AMP的努力。鉴于此，目前只有少数AMP在临床试验中。肽模拟物（如拟肽）已成为AMP的极有希望的替代品，因为它们对酶促降解具有内在的稳定性，并显示出强大的抗菌性能。这篇专题文章重点介绍了在开发新型抗感染类肽方面所取得的进展。
更新日期：2020-09-24
中文翻译：
抗感染类肽研究的最新进展。
在寻找抗菌素的新来源时，许多研究人员已经研究了抗菌肽（AMP）作为设计创新疗法的模板。然而，由于其固有的对酶促降解的敏感性，严重阻碍了在该领域开发AMP的努力。鉴于此，目前只有少数AMP在临床试验中。肽模拟物（如拟肽）已成为AMP的极有希望的替代品，因为它们对酶促降解具有内在的稳定性，并显示出强大的抗菌性能。这篇专题文章重点介绍了在开发新型抗感染类肽方面所取得的进展。
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