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QuEChERS: a simple extraction for monitoring quaternary ammonium biocide pollution in soils and antimicrobial resistance.
Analytical Methods ( IF 2.7 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0ay01324b A Ruth Godfrey 1 , Rachel Townsend , Claire Desbrow , Celeste Felion
Analytical Methods ( IF 2.7 ) Pub Date : 2020-08-28 , DOI: 10.1039/d0ay01324b A Ruth Godfrey 1 , Rachel Townsend , Claire Desbrow , Celeste Felion
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Quaternary ammonium compounds (QACs) are broad-spectrum disinfectants used in a range of everyday materials. Their high usage rates, limited regulation and reporting has meant their environmental release is largely uncontrolled and impact unknown. With links to antimicrobial resistance (AMR) and adsorption to wastewater solids (that are recycled), there is a need for more controlled disposal measures and monitoring. These environmental matrices are highly complex requiring methods that are often laborious and costly to undertake. Using a robust quantitative reversed-phase LC-MS/MS method, we have shown that an ‘off the shelf’ QuEChERS product can reliably extract (<10% RSD) aromatic and aliphatic QACs anticipated within municipal, industrial and agricultural waste from water and soil, with reduced matrix effects of 95.7–104.4% for recoveries of up to 53% from soil when combined with extract dilution. Therefore, unlike current literature, this work has shown that, with minimal development, the QuEChERS product can provide a rapid, effective and low cost preparation for quantifying QAC pollution and monitoring AMR.
中文翻译：
QuEChERS：一种简单的提取物，用于监测土壤中季铵杀生物剂的污染和抗药性。
季铵化合物（QAC）是广泛用于日常材料的广谱消毒剂。它们的高使用率，有限的法规和报告意味着它们的环境释放在很大程度上不受控制并且影响未知。与抗菌素耐药性（AMR）和对废水固体（循环利用）的吸附相关联，因此需要更加可控的处置措施和监测。这些环境矩阵非常复杂，需要通常费力且昂贵的方法。使用可靠的定量反相LC-MS / MS方法，我们已经表明，“现成的” QuEChERS产品可以可靠地从水中和水中提取市政，工业和农业废物中预期的芳香族和脂肪族QAC（<10％RSD）。土壤，基质效应降低了95.7–104。结合提取物稀释液，从土壤中回收率最高为53％时为4％。因此，与当前的文献不同，这项工作表明，QuEChERS产品经过最少的开发，即可为定量QAC污染和监测AMR提供快速，有效和低成本的制备方法。
更新日期：2020-09-17
中文翻译：
QuEChERS：一种简单的提取物，用于监测土壤中季铵杀生物剂的污染和抗药性。
季铵化合物（QAC）是广泛用于日常材料的广谱消毒剂。它们的高使用率，有限的法规和报告意味着它们的环境释放在很大程度上不受控制并且影响未知。与抗菌素耐药性（AMR）和对废水固体（循环利用）的吸附相关联，因此需要更加可控的处置措施和监测。这些环境矩阵非常复杂，需要通常费力且昂贵的方法。使用可靠的定量反相LC-MS / MS方法，我们已经表明，“现成的” QuEChERS产品可以可靠地从水中和水中提取市政，工业和农业废物中预期的芳香族和脂肪族QAC（<10％RSD）。土壤，基质效应降低了95.7–104。结合提取物稀释液，从土壤中回收率最高为53％时为4％。因此，与当前的文献不同，这项工作表明，QuEChERS产品经过最少的开发，即可为定量QAC污染和监测AMR提供快速，有效和低成本的制备方法。
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