In the current study, a green, cost-effective, and bio-degradable additive was used for the preparation of a highly efficient sorbent based on silicon glue. Here, a banana peel was pretreated and mixed with silicon glue. It was proved that the prepared banana peel–silicon glue bar is a reliable sorbent for stir bar sorptive extraction of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, diclofenac, ibuprofen and mefenamic acid in human urine and plasma. Compared to the lab-made sorbents, the prepared sorbent showed high extraction performance, high stability, and satisfactory reproducibility and involved easy preparation. In order to optimize the effective factors, different parameters such as (stirring rate, pH, extraction time, desorption time and elution solvent volume) were optimized using response surface methodology (RSM) through applying Central-Composite Design (CCD). Under the optimum conditions, the linear dynamic ranges of the target analytes were investigated in the range of 0.2–200 μg L⁻¹ with r² higher than 0.9929. Limits of detection (LODs) and limits of quantification (LOQs) of analytes were in the ranges of 0.04–0.5 and 0.15–1.65, respectively. The reproducibility of the method was also investigated by calculating the relative standard deviation. The RSD was measured to be lower than 4.9%. Bar-to-bar reproducibility at a 100 μg L⁻¹ concentration level was also evaluated to be lower than 5.3% (n = 3). Also, each prepared film can be used up to 64 times without any reduction in extraction performance. Finally, the method was successfully applied for the determination of selected drugs in different biological fluids including urine and plasma samples. The calculated relative recovery in real sample analysis was higher than 90%.

中文翻译：

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香蕉皮/硅胶涂层搅拌棒，用于提取阿司匹林，双氯芬酸，布洛芬和甲芬那酸，然后进行高效液相色谱-UV检测。

在当前的研究中，绿色，经济高效且可生物降解的添加剂被用于制备基于硅胶的高效吸附剂。在这里，香蕉皮经过预处理并与硅胶混合。事实证明，制备的香蕉皮-硅树脂胶条是搅拌棒吸附提取人尿液和血浆中非甾体抗炎药（NSAIDs）（包括阿司匹林，双氯芬酸，布洛芬和甲芬那酸）的可靠吸附剂。与实验室制得的吸附剂相比，所制备的吸附剂具有萃取性能高，稳定性高，重现性好，制备容易等特点。为了优化有效因子，需要使用不同的参数，例如（搅拌速度，pH，提取时间，通过应用中央复合设计（CCD），使用响应表面方法（RSM）来优化解吸时间和洗脱溶剂体积）。在最佳条件下，研究了目标分析物的线性动态范围为0.2–200μgL^-1， r ²高于0.9929。分析物的检出限（LOD）和定量限（LOQ）分别在0.04–0.5和0.15–1.65之间。还通过计算相对标准偏差研究了该方法的重现性。测得的RSD低于4.9％。还评估了在100μgL ^-1浓度水平下的条间重现性低于5.3％（ n= 3）。而且，每个制备的膜可以使用多达64次，而不会降低提取性能。最终，该方法成功地用于测定包括尿液和血浆样品在内的不同生物流体中的选定药物。实际样品分析中计算出的相对回收率高于90％。