Background Neuroblastoma (NB) is the most common extracellular solid tumor among children accounting for serious mortality. Macroautophagy, a common housekeeping mechanism to maintain cellular homeostasis in eukaryotic cells, is involved in tumorigenesis and chemoresistance in a spectrum of cancers. Data resources Based on the terms of ‘autophagy’ and ‘neuroblastoma’, all the recent literature was searched and reviewed through PubMed. Results Autophagy is associated with apoptosis, histone modifications, angiogenesis, metabolism in NB. With those facts we assume that NB is an autophagy-dependent tumor, which means that autophagy inhibition therapy is desirable. Conclusion Autophagy in NB is pro-oncogenic, so inhibiting autophagy in high-risk NB may benefit treatment outcomes.

中文翻译：

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靶向神经母细胞瘤中的自噬

背景 神经母细胞瘤 (NB) 是儿童中最常见的细胞外实体瘤，死亡率很高。巨自噬是真核细胞中维持细胞稳态的一种常见管家机制，参与一系列癌症的肿瘤发生和化学抗性。数据资源 基于“自噬”和“神经母细胞瘤”的术语，通过 PubMed 搜索和回顾了所有近期文献。结果 自噬与 NB 中的细胞凋亡、组蛋白修饰、血管生成、代谢有关。根据这些事实，我们假设 NB 是一种自噬依赖性肿瘤，这意味着自噬抑制疗法是可取的。结论 NB 中的自噬是促癌基因，因此抑制高危 NB 中的自噬可能有益于治疗结果。