Diabetic retinopathy (DR) research has had significant advancements over the past decades. We analysed the impact and characteristics of the top 100 (T100) most-cited articles in DR research. The Scopus database was searched for articles published from 1960 to June 2020 by two independent investigators. The T100 DR articles were published between 1961 and 2017 with median citations of 503 (range: 306–20 100); 84% were published after 1990. More than half (59%) were published in general medical/diabetes journals while 37% in ophthalmology journals. The top six journals contributed to 56% of the T100: Ophthalmology (n=13), Archives of Ophthalmology (n=12), Diabetes (n=9), New England Journal of Medicine (n=8), Journal of the American Medical Association (n=7) and The Lancet (n=7). Although observational studies were most popular (33%), randomised controlled trials (RCTs, 24%) published in journals with higher impact factor (IF) and citations (median IF and citations=7.113, 503 vs 21.437, 696.5, both p-value<0.05). 33 of the T100 were cited by several international DR clinical guidelines. The USA contributed to 63% of T100, but 18% of articles published after 2000 came from Asia. More than 80% of both first and last authors were men. Artificial intelligence (AI) to screen for DR ranked 14th and 99th despite recent publications in 2016 and 2017, respectively. To conclude, our T100 analysis showed that RCTs were most-cited and more articles were published in non-ophthalmology than ophthalmology journals. It highlights the impact the T100 DR has in shaping guidelines used to date in DR management, identifies AI for DR screening as an emerging area and shows a contemporary rise of Asian contribution in DR research.

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关于糖尿病视网膜病变的 100 篇被引用次数最多的文章

在过去的几十年中，糖尿病视网膜病变 (DR) 研究取得了重大进展。我们分析了 DR 研究中被引用次数最多的 100 篇 (T100) 文章的影响和特征。Scopus 数据库由两名独立研究人员搜索了 1960 年至 2020 年 6 月发表的文章。T100 DR 文章发表于 1961 年至 2017 年，中位引用次数为 503（范围：306-20 100）；84% 发表于 1990 年之后。超过一半 (59%) 发表于一般医学/糖尿病期刊，而 37% 发表于眼科期刊。排名前六的期刊贡献了 56% 的 T100：眼科 (n=13)、眼科档案 (n=12)、糖尿病 (n=9)、新英格兰医学杂志 (n=8)、美国杂志医学协会 (n=7) 和柳叶刀 (n=7)。尽管观察性研究最受欢迎（33%），随机对照试验 (RCTs, 24%) 发表在影响因子 (IF) 和引用次数较高的期刊上（中位 IF 和引用次数=7.113, 503 vs 21.437, 696.5，p 值均<0.05）。T100 中有 33 个被多个国际 DR 临床指南引用。美国贡献了 T100 的 63%，但 2000 年之后发表的文章中有 18% 来自亚洲。超过 80% 的第一作者和最后作者是男性。尽管最近分别在 2016 年和 2017 年发表了文章，但用于筛查 DR 的人工智能 (AI) 排名第 14 位和第 99 位。总而言之，我们的 T100 分析显示，RCT 被引用最多，并且在非眼科期刊上发表的文章多于眼科期刊。它强调了 T100 DR 在制定迄今为止用于 DR 管理的指南方面的影响，