The purpose of this study was to prepare a liposomal temperature-sensitive gel able to slowly release resveratrol after local intramuscular injection. The best formulation of resveratrol liposomes was based on the highest encapsulation efficiency and drug loading designed by Box-Behnken. The prepared liposomes were approximately circular, with a mean particle diameter of and zeta potential of -6.9 mV. The optimized liposomes were dispersed in a polymer gel (PLGA-PEG-PLGA) for preparation of an in situ-formed gel at . In vitro release of the prepared liposome temperature-sensitive gel was studied and compared with ordinary drug-releasing gels, revealing a significantly longer drug release time. Finally, a rat sciatic nerve injury model was used to evaluate the pharmacological activity of the liposome temperature-sensitive gels for the repair of damaged nerves. The results indicate that the gel was able to promote recovery of damaged nerves.

中文翻译：

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白藜芦醇脂质体胶囊热敏凝胶的制备及其修复大鼠坐骨神经损伤的能力评价

这项研究的目的是制备一种脂质体温度敏感性凝胶，在局部肌肉注射后能够缓慢释放白藜芦醇。白藜芦醇脂质体的最佳配方是基于Box-Behnken设计的最高包封效率和最高载药量。制备的脂质体约为圆形，平均粒径为和zeta电位为-6.9 mV。将优化的脂质体分散在聚合物凝胶（PLGA-PEG-PLGA）中，用于制备原位形成的凝胶。。 对制备的脂质体温度敏感性凝胶的体外释放进行了研究，并将其与普通的药物释放凝胶进行了比较，显示出明显更长的药物释放时间。最后，使用大鼠坐骨神经损伤模型来评估脂质体温度敏感性凝胶对受损神经的修复的药理活性。结果表明该凝胶能够促进受损神经的恢复。