Controlled Production of Elastin-like Recombinamer Polymer-Based Membranes at a Liquid-Liquid Interface by Click Chemistry.,Biomacromolecules

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Controlled Production of Elastin-like Recombinamer Polymer-Based Membranes at a Liquid-Liquid Interface by Click Chemistry.
Biomacromolecules ( IF 5.5 ) Pub Date : 2020-08-27 , DOI: 10.1021/acs.biomac.0c00939
Miguel González-Pérez ₁ , Israel González de Torre ₁ , Matilde Alonso ₁ , José Carlos Rodríguez-Cabello ₁

Affiliation

Diffusion of organic and inorganic molecules controls most industrial and biological processes that occur in a liquid phase. Although significant efforts have been devoted to the design and operation of large-scale purification systems, diffusion devices with adjustable biochemical characteristics have remained difficult to achieve. In this regard, micrometer-scale, bioinspired membranes with tunable diffusion properties have been engineered by covalent cross-linking of two elastin-like recombinamers (ELRs) at a liquid–liquid interface. The covalent approach selected provides the desired ELR-based membranes with structural support, and modulation of the concentration of the polypeptides employed confers direct control of the thickness, pore size, and diffusive properties over a broad range of molecular weights (4–150 kDa). The recombinant and versatile nature of the proteinaceous building blocks employed further paves the way to engineering bioactive motifs within the membrane scaffold, thereby widening their applicability in the biological field.

中文翻译：

通过点击化学在液-液界面上受控地生产基于弹性蛋白的重组聚合物基膜。

有机和无机分子的扩散控制着液相中发生的大多数工业和生物过程。尽管已经为大型纯化系统的设计和操作做出了巨大的努力，但是具有可调节的生化特性的扩散装置仍然难以实现。在这方面，通过在液体-液体界面处两个弹性蛋白样重组体（ELR）的共价交联，设计了具有可调扩散特性的微米级生物启发膜。选择的共价方法可为所需的基于ELR的膜提供结构支持，并且对所用多肽浓度的调节可在较宽的分子量范围（4–150 kDa）范围内直接控制厚度，孔径和扩散特性。

更新日期：2020-10-12

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