The enhanced danger of physicians' off-label prescribing during a public health emergency.,Journal of Law and the Biosciences

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The enhanced danger of physicians' off-label prescribing during a public health emergency.
Journal of Law and the Biosciences ( IF 3.4 ) Pub Date : 2020-06-28 , DOI: 10.1093/jlb/lsaa031
Doriane Lambelet Coleman ₁ , Philip M Rosoff ₂

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On Dec. 26, 2019, a 41-year-old man was admitted to a hospital in Wuhan City, China, with flu-like symptoms including fever, painful cough, fatigue, and generalized achiness that began about a week before he presented for medical care. A novel coronavirus was isolated from his respiratory secretions that was genetically related to the pathogenic coronaviruses that cause SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory distress syndrome).¹ This virus is the etiologic agent that causes the disease now known as COVID-19 that is sweeping the globe. It is highly contagious and transmissible with an R₀ estimated to be between 1.4 and 3.28.² To date there is no known effective antiviral treatment or vaccine; current therapy for those most severely affected consists of supportive care. The overall case fatality rate is about 2.3 per cent.³

更新日期：2020-08-28

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