To determine whether performance on the Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) can differentiate between cognitively intact carriers of an autosomal dominant Alzheimer’s disease mutation (E280A) in Presenilin-1, who are destined to develop early-onset dementia, from matched non-carriers. We also sought to examine whether LAS-FNAME performance is associated with amyloid-β and regional tau burden in mutation carriers.

中文翻译：

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A-05人脸名称联想记忆测验的拉丁美洲西班牙语版本对临床前常染色体显性阿尔茨海默氏病的认知和病理变化敏感

若要确定在拉丁美洲西班牙语版本的人名联想记忆测验（LAS-FNAME）上的表现是否可以区分早老1的常染色体显性遗传阿尔茨海默氏病突变（E280A）的认知完好携带者，这些人注定要早期发育匹配的非携带者引起的痴呆发作。我们还试图检查LAS-FNAME的性能是否与淀粉样β和突变载体中的区域tau负担有关。