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Ultrasound-promoted solvent-free synthesis of some new α-aminophosphonates as potential antioxidants
Main Group Metal Chemistry ( IF 1.8 ) Pub Date : 2020-08-28 , DOI: 10.1515/mgmc-2020-0018
Meson Haji Basha 1 , Chennamasetty Subramanyam 2 , Kammela Prasada Rao 2
Affiliation  

Abstract Ultrasonic irradiation has been adopted in order to achieve an efficient synthesis of some novel α-aminophosphonates by Pudovik reaction. Major benefits of this method are as follows: eco-friendly, free of catalyst, high yielding, uncomplicated work-up procedure, short reaction time, and solvent free condition. Spectral characterisation and elemental analysis of the synthesized samples was carried out. In vitro antioxidant activity of the title compounds was screened by DPPH˙, O2-˙ and NO˙ scavenging methods. Good activity was shown by most of the compounds as compared with the standards.

中文翻译:

超声促进无溶剂合成一些新的α-氨基膦酸盐作为潜在的抗氧化剂

摘要 为了通过Pudovik反应高效合成一些新型α-氨基膦酸酯,已采用超声波辐照。该方法的主要优点如下:环保、无催化剂、收率高、后处理程序简单、反应时间短、无溶剂条件。对合成样品进行光谱表征和元素分析。通过DPPH·、O2-·和NO·清除方法筛选标题化合物的体外抗氧化活性。与标准品相比,大多数化合物显示出良好的活性。
更新日期:2020-08-28
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