Mizoroki–Heck reaction of 1,2-disubstituted aryl alkenes: Variables of synthesis, solvent and ligand modulation of reactivity,Synthetic Communications

当前位置： X-MOL 学术 › Synth. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Mizoroki–Heck reaction of 1,2-disubstituted aryl alkenes: Variables of synthesis, solvent and ligand modulation of reactivity
Synthetic Communications ( IF 1.8 ) Pub Date : 2020-08-27 , DOI: 10.1080/00397911.2020.1811986
Pronnoy G. Bangar _{1,

2} , Priyanka R. Jawalkar ₁ , Swapnil R. Dumbre ₁ , Pallavi K. Raut ₁ , Dharmaraj J. Patil ₁ , Neethu Tv ₁ , Shana Sudhakaran ₁ , Suresh Iyer _{1,

2}

Affiliation

Abstract Reaction of aryl iodides with 1,2-disubstituted aryl alkenes in the presence of TBABr/TBACl gave high yields of the Mizoroki–Heck product. Phosphine ligands were used for the modulation of reactivity and stereoselectivity, for the reaction of 4-iodoanisole with cinnamaldehyde. tert-Bu3P.HBF4 gave the highest E:Z ratio of 1:0.08. The use of PEG-200 and PEG-400 as solvent could activate the reaction of aryl iodides with various 1,2-disubstituetd aryl alkenes. Graphical Abstract

中文翻译：

1,2-二取代芳基烯烃的 Mizoroki-Heck 反应：合成变量、溶剂和配体调节反应性

摘要在 TBABr/TBACl 存在下，芳基碘化物与 1,2-二取代芳基烯烃反应得到高产率的 Mizoroki-Heck 产物。膦配体用于调节反应性和立体选择性，用于 4-碘苯甲醚与肉桂醛的反应。tert-Bu3P.HBF4 的 E:Z 比最高，为 1:0.08。使用 PEG-200 和 PEG-400 作为溶剂可以激活芳基碘化物与各种 1,2-二取代芳基烯烃的反应。图形概要

更新日期：2020-08-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11